GPER Antibody

• Background:

  This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized. [provided by RefSeq].

• NCBI Gene ID:

  2852

• Swiss Prot:

  Q99527

• Accession Number:

  Q99527

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This GPER antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 346-375 amino acids from the C-terminal region of human GPER.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Neuroscience, Signal Transduction, Growth Factors

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  42 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  GPER1

• NCBI Official Name:

  G-protein coupled estrogen receptor 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Patel, V.H., et al. Int. J. Mol. Med. 26 (2) :193-199 (2010)

• Background Reference 02:

  Ignatov, A., et al. Breast Cancer Res. Treat. 123 (1) :87-96 (2010)

• Background Reference 03:

  Li, Y., et al. Mol. Endocrinol. 24 (5) :969-980 (2010)

• Background Reference 04:

  Kang, L., et al. Mol. Endocrinol. 24 (4) :709-721 (2010)

• Other Product Names:

  G-protein coupled estrogen receptor 1, Chemoattractant receptor-like 2, Flow-induced endothelial G-protein coupled receptor 1, FEG-1, G protein-coupled estrogen receptor 1, G-protein coupled receptor 30, GPCR-Br, IL8-related receptor DRY12, Lymphocyte-derived G-protein coupled receptor, LYGPR, Membrane estrogen receptor, mER, GPER1, CEPR, CMKRL2, DRY12, GPER, GPR30

• Tested Applications:

  WB

• Protein ID:

  3023539

• Physical Properties:

  Liquid