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GPER Antibody

CAT: 0223-58-136Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-58-136Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized. [provided by RefSeq].
NCBI Gene ID
2852
Swiss Prot
Q99527
Accession Number
Q99527
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This GPER antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 346-375 amino acids from the C-terminal region of human GPER.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Neuroscience, Signal Transduction, Growth Factors
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
42 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
GPER1
NCBI Official Name
G-protein coupled estrogen receptor 1
NCBI Organism
Homo sapiens
Background Reference 01
Patel, V.H., et al. Int. J. Mol. Med. 26 (2) :193-199 (2010)
Background Reference 02
Ignatov, A., et al. Breast Cancer Res. Treat. 123 (1) :87-96 (2010)
Background Reference 03
Li, Y., et al. Mol. Endocrinol. 24 (5) :969-980 (2010)
Background Reference 04
Kang, L., et al. Mol. Endocrinol. 24 (4) :709-721 (2010)
Other Product Names
G-protein coupled estrogen receptor 1, Chemoattractant receptor-like 2, Flow-induced endothelial G-protein coupled receptor 1, FEG-1, G protein-coupled estrogen receptor 1, G-protein coupled receptor 30, GPCR-Br, IL8-related receptor DRY12, Lymphocyte-derived G-protein coupled receptor, LYGPR, Membrane estrogen receptor, mER, GPER1, CEPR, CMKRL2, DRY12, GPER, GPR30
Tested Applications
WB
Protein ID
3023539
Physical Properties
Liquid

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