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POLG Antibody

CAT: 0223-58-118Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-118Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE) . Two transcript variants encoding the same protein have been found for this gene.
NCBI Gene ID
5428
Swiss Prot
P54098
Accession Number
P54098
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This POLG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1120-1148 amino acids from the C-terminal region of human POLG.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
140 kDa
Fragment
Rabbit Ig
Symbol
POLG
NCBI Official Name
DNA polymerase subunit gamma-1
NCBI Organism
Homo sapiens
Background Reference 01
Tong, Z.B., et al. Fertil. Steril. 94 (7) :2932-2934 (2010)
Background Reference 02
Stewart, J.D., et al. Hepatology 52 (5) :1791-1796 (2010)
Background Reference 03
Batabyal, D., et al. J. Biol. Chem. 285 (44) :34191-34201 (2010)
Background Reference 04
Wang, W., et al. Nucleic Acids Res. (2010) In press :
Other Product Names
DNA polymerase subunit gamma-1, Mitochondrial DNA polymerase catalytic subunit, PolG-alpha, POLG, MDP1, POLG1, POLGA
Tested Applications
WB, IHC-P, IF, Flow
Protein ID
1706507
Physical Properties
Liquid

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