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ALPP Antibody

CAT: 0223-58-109Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-109Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific) . The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized.
NCBI Gene ID
250
Swiss Prot
P05187
Accession Number
P05187
Host
Rabbit
Reactivity
Human
Immunogen
This ALPP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-83 amino acids from the N-terminal region of human ALPP.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
58 kDa
Fragment
Rabbit Ig
Symbol
ALPP
NCBI Official Name
Alkaline phosphatase, placental type
NCBI Organism
Homo sapiens
Background Reference 01
Stec, B., et al. Acta Crystallogr. Sect.Struct. Biol. Cryst. Commun. 66 (PT 8), 866-870 (2010) :
Background Reference 02
Wang, F., et al. Am. J. Surg. Pathol. 33 (10) :1529-1539 (2009)
Background Reference 03
Estrada, K., et al. Hum. Mol. Genet. 18 (18) :3516-3524 (2009)
Background Reference 04
Zhu, J.F., et al. Zhonghua Wai Ke Za Zhi 47 (5) :381-384 (2009)
Other Product Names
Alkaline phosphatase, placental type, Alkaline phosphatase Regan isozyme, Placental alkaline phosphatase 1, PLAP-1, ALPP, PLAP
Tested Applications
WB, IHC-P
Protein ID
130737
Physical Properties
Liquid

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