ALPP Antibody

• Background:

  There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific) . The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized.

• NCBI Gene ID:

  250

• Swiss Prot:

  P05187

• Accession Number:

  P05187

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ALPP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-83 amino acids from the N-terminal region of human ALPP.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Immunology

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  58 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  ALPP

• NCBI Official Name:

  Alkaline phosphatase, placental type

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Stec, B., et al. Acta Crystallogr. Sect.Struct. Biol. Cryst. Commun. 66 (PT 8), 866-870 (2010) :

• Background Reference 02:

  Wang, F., et al. Am. J. Surg. Pathol. 33 (10) :1529-1539 (2009)

• Background Reference 03:

  Estrada, K., et al. Hum. Mol. Genet. 18 (18) :3516-3524 (2009)

• Background Reference 04:

  Zhu, J.F., et al. Zhonghua Wai Ke Za Zhi 47 (5) :381-384 (2009)

• Other Product Names:

  Alkaline phosphatase, placental type, Alkaline phosphatase Regan isozyme, Placental alkaline phosphatase 1, PLAP-1, ALPP, PLAP

• Tested Applications:

  WB, IHC-P

• Protein ID:

  130737

• Physical Properties:

  Liquid