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SECISBP2 Antibody

CAT: 0223-58-088Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-088Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism.
NCBI Gene ID
79048
Swiss Prot
Q96T21
Accession Number
Q96T21
Host
Rabbit
Reactivity
Human
Immunogen
This SECISBP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 501-530 amino acids from the Central region of human SECISBP2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
95 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
SECISBP2
NCBI Official Name
Selenocysteine insertion sequence-binding protein 2
NCBI Organism
Homo sapiens
Background Reference 01
Meplan, C., et al. Carcinogenesis 31 (6) :1074-1079 (2010)
Background Reference 02
Papp, L.V., et al. Antioxid. Redox Signal. 12 (7) :797-808 (2010)
Background Reference 03
Di Cosmo, C., et al. J. Clin. Endocrinol. Metab. 94 (10) :4003-4009 (2009)
Background Reference 04
Olieric, V., et al. Biochimie 91 (8) :1003-1009 (2009)
Other Product Names
Selenocysteine insertion sequence-binding protein 2, SECIS-binding protein 2, SECISBP2, SBP2
Tested Applications
WB
Protein ID
52788293
Physical Properties
Liquid

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