SECISBP2 Antibody

• Background:

  The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism.

• NCBI Gene ID:

  79048

• Swiss Prot:

  Q96T21

• Accession Number:

  Q96T21

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SECISBP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 501-530 amino acids from the Central region of human SECISBP2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  95 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  SECISBP2

• NCBI Official Name:

  Selenocysteine insertion sequence-binding protein 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Meplan, C., et al. Carcinogenesis 31 (6) :1074-1079 (2010)

• Background Reference 02:

  Papp, L.V., et al. Antioxid. Redox Signal. 12 (7) :797-808 (2010)

• Background Reference 03:

  Di Cosmo, C., et al. J. Clin. Endocrinol. Metab. 94 (10) :4003-4009 (2009)

• Background Reference 04:

  Olieric, V., et al. Biochimie 91 (8) :1003-1009 (2009)

• Other Product Names:

  Selenocysteine insertion sequence-binding protein 2, SECIS-binding protein 2, SECISBP2, SBP2

• Tested Applications:

  WB

• Protein ID:

  52788293

• Physical Properties:

  Liquid