CACNB2 Antibody

• Background:

  This gene encodes a subunit of a voltage-dependent calcium channel protein which is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome which is an autoimmune disorder. Mutations in this gene are associated with Brugada symdrome. Alternatively spliced variants have been identified for this gene.

• NCBI Gene ID:

  783

• Swiss Prot:

  Q08289

• Accession Number:

  Q08289

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CACNB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 232-261 amino acids from the Central region of human CACNB2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rabbit, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  74 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CACNB2

• NCBI Official Name:

  Voltage-dependent L-type calcium channel subunit beta-2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Burashnikov, E., et al. Heart Rhythm (2010) In press :

• Background Reference 02:

  Shimada, M., et al. Hum. Genet. 128 (4) :433-441 (2010)

• Background Reference 03:

  Takeuchi, F., et al. Circulation 121 (21) :2302-2309 (2010)

• Background Reference 04:

  Hong, K.W., et al. J. Hum. Genet. 55 (6) :336-341 (2010)

• Other Product Names:

  Voltage-dependent L-type calcium channel subunit beta-2, CAB2, Calcium channel voltage-dependent subunit beta 2, Lambert-Eaton myasthenic syndrome antigen B, MYSB, CACNB2, CACNLB2, MYSB

• Tested Applications:

  WB

• Protein ID:

  145559447

• Physical Properties:

  Liquid