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CACNB4 Antibody

CAT: 0223-28-224Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-28-224Size:100 µL
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Background
CACNB4 is a member of the beta subunit family, a protein in the voltage-dependent calcium channel complex. CACNB4 plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. This gene encodes a member of the beta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein described in this record plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME) . Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.
NCBI Gene ID
785
Swiss Prot
O00305-2
Accession Number
NP_001005747
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CACNB4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Membrane
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store CACNB4 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
55 kDa
Applications Notes
CACNB4 antibody can be used for detection of CACNB4 by ELISA at 1:312500. CACNB4 antibody can be used for detection of CACNB4 by western blot at 0.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
CACNB4
NCBI Official Name
Calcium channel, voltage-dependent, beta 4 subunit
NCBI Organism
Homo sapiens
Background Reference 01
Kobayashi, T., (2007) Biochem. Biophys. Res. Commun. 360 (3), 679-683.
Other Product Names
CACNB4, CAB4, CACNLB4, EA5, EJM, EIG9, EJM4, EJM6
Tested Applications
ELISA, WB
Protein ID
54607068
Physical Properties
Liquid

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