Mouse Gsk3b Antibody

• Background:

  Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. May phosphorylate MUC1 and decrease the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1 (By similarity) .

• NCBI Gene ID:

  56637

• Swiss Prot:

  Q9WV60

• Accession Number:

  Q9WV60

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  This Mouse Gsk3b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-59 amino acids from the N-terminal region of mouse Gsk3b.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Cell Cycle, Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Human, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  47 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  Gsk3b

• NCBI Official Name:

  Glycogen synthase kinase-3 beta

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Liu, Y., et al. Diabetologia 53 (12) :2600-2610 (2010)

• Background Reference 02:

  Graham, J.A., et al. J. Biol. Chem. 285 (43) :32852-32859 (2010)

• Background Reference 03:

  Ahmad, I., et al. Oncogene (2010) In press :

• Background Reference 04:

  Asada, N., et al. J. Neurosci. 30 (26) :8852-8865 (2010)

• Other Product Names:

  Glycogen synthase kinase-3 beta, GSK-3 beta, Serine/threonine-protein kinase GSK3B, Gsk3b

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid