SSRP1 Antibody

• Background:

  The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known.

• NCBI Gene ID:

  6749

• Swiss Prot:

  Q08945

• Accession Number:

  Q08945

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SSRP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 490-518 amino acids from the C-terminal region of human SSRP1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  81 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  SSRP1

• NCBI Official Name:

  FACT complex subunit SSRP1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Zeng, S.X., et al. Mol. Cell. Biol. 30 (4) :935-947 (2010)

• Background Reference 02:

  Hautbergue, G.M., et al. Curr. Biol. 19 (22) :1918-1924 (2009)

• Background Reference 03:

  Hu, J., et al. J. Virol. 83 (21) :11051-11063 (2009)

• Background Reference 04:

  Kumari, A., et al. J. Cell. Biochem. 108 (2) :508-518 (2009)

• Other Product Names:

  FACT complex subunit SSRP1, Chromatin-specific transcription elongation factor 80 kDa subunit, Facilitates chromatin transcription complex 80 kDa subunit, FACT 80 kDa subunit, FACTp80, Facilitates chromatin transcription complex subunit SSRP1, Recombination signal sequence recognition protein 1, Structure-specific recognition protein 1, hSSRP1, T160, SSRP1, FACT80

• Tested Applications:

  WB

• Physical Properties:

  Liquid