PKD2 Antibody

• Background:

  This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. The encoded protein may function in renal tubular development, morphology, and function, and may modulate intracellular calcium homoeostasis and other signal transduction pathways. This protein interacts with polycystin 1 to produce cation-permeable currents. Mutations in this gene have been associated with autosomal dominant polycystic kidney disease.

• NCBI Gene ID:

  5311

• Swiss Prot:

  Q13563

• Accession Number:

  Q13563

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  This PKD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 874-903 amino acids from the C-terminal region of human PKD2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  110 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  PKD2

• NCBI Official Name:

  Polycystin-2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Duning, K., et al. J. Biol. Chem. 285 (44) :33584-33588 (2010)

• Background Reference 02:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 03:

  Stewart, A.P., et al. Biophys. J. 99 (3) :790-797 (2010)

• Background Reference 04:

  Petri, E.T., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (20) :9176-9181 (2010)

• Other Product Names:

  Polycystin-2, Autosomal dominant polycystic kidney disease type II protein, Polycystic kidney disease 2 protein, Polycystwin, R48321, PKD2

• Tested Applications:

  WB

• Protein ID:

  116242717

• Physical Properties:

  Liquid