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PKD2 Antibody

CAT: 0223-58-019Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-019Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. The encoded protein may function in renal tubular development, morphology, and function, and may modulate intracellular calcium homoeostasis and other signal transduction pathways. This protein interacts with polycystin 1 to produce cation-permeable currents. Mutations in this gene have been associated with autosomal dominant polycystic kidney disease.
NCBI Gene ID
5311
Swiss Prot
Q13563
Accession Number
Q13563
Host
Rabbit
Reactivity
Mouse
Immunogen
This PKD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 874-903 amino acids from the C-terminal region of human PKD2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
110 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PKD2
NCBI Official Name
Polycystin-2
NCBI Organism
Homo sapiens
Background Reference 01
Duning, K., et al. J. Biol. Chem. 285 (44) :33584-33588 (2010)
Background Reference 02
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 03
Stewart, A.P., et al. Biophys. J. 99 (3) :790-797 (2010)
Background Reference 04
Petri, E.T., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (20) :9176-9181 (2010)
Other Product Names
Polycystin-2, Autosomal dominant polycystic kidney disease type II protein, Polycystic kidney disease 2 protein, Polycystwin, R48321, PKD2
Tested Applications
WB
Protein ID
116242717
Physical Properties
Liquid

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