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WWOX Antibody

CAT: 0223-57-993Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-993Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD) . The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms.
NCBI Gene ID
51741
Swiss Prot
Q9NZC7
Accession Number
Q9NZC7
Host
Rabbit
Reactivity
Mouse
Immunogen
This WWOX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 369-396 amino acids from the C-terminal region of human WWOX.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
47 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
WWOX
NCBI Official Name
WW domain-containing oxidoreductase
NCBI Organism
Homo sapiens
Background Reference 01
Maeda, N., et al. Virchows Arch. 457 (4) :423-432 (2010)
Background Reference 02
Baykara, O., et al. Tumour Biol. 31 (4) :315-320 (2010)
Background Reference 03
Kurek, K.C., et al. Cancer Res. 70 (13) :5577-5586 (2010)
Background Reference 04
Lin, J., et al. Zhonghua Gan Zang Bing Za Zhi 18 (5) :357-360 (2010)
Other Product Names
WW domain-containing oxidoreductase, 111-, Fragile site FRA16D oxidoreductase, WWOX, FOR, WOX1
Tested Applications
WB
Protein ID
74725363
Physical Properties
Liquid

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