ALDH1A1 Antibody

• Background:

  ALDH1A1 belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme.

• NCBI Gene ID:

  216

• Swiss Prot:

  P00352

• Accession Number:

  P00352

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ALDH1A1 antibody is generated from rabbits immunized with human ALDH1A1 recombinant protein.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  55 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  ALDH1A1

• NCBI Official Name:

  Retinal dehydrogenase 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  References for protein:

• Background Reference 02:

  Moore, S., Stud Alcohol Drugs 68 (2), 192-196 (2007)

• Background Reference 03:

  Collard, F., Biochimie 89 (3), 369-373 (2007)

• Background Reference 04:

  References for HepG2 cell line:

• Other Product Names:

  Retinal dehydrogenase 1, RALDH 1, RalDH1, ALDH-E1, ALHDII, Aldehyde dehydrogenase family 1 member A1, Aldehyde dehydrogenase, cytosolic, ALDH1A1, ALDC, ALDH1, PUMB1

• Tested Applications:

  WB, IHC-P, IF, Flow

• Protein ID:

  118495

• Physical Properties:

  Liquid