LRP5 Antibody

• Background:

  This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy.

• NCBI Gene ID:

  4041

• Swiss Prot:

  O75197

• Accession Number:

  O75197

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  This LRP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1163-1190 amino acids from the C-terminal region of human LRP5.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  179 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  LRP5

• NCBI Official Name:

  Low-density lipoprotein receptor-related protein 5

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 02:

  Lee, D.Y., et al. Menopause 17 (5) :1064-1070 (2010)

• Background Reference 03:

  Liu, J.M., et al. J. Clin. Endocrinol. Metab. 95 (9), E112-E120 (2010) :

• Background Reference 04:

  Paternoster, L., et al. J. Clin. Endocrinol. Metab. 95 (8) :3940-3948 (2010)

• Other Product Names:

  Low-density lipoprotein receptor-related protein 5, LRP-5, LRP5, LR3, LRP7

• Tested Applications:

  WB

• Physical Properties:

  Liquid