Mouse Mapk8 Antibody

• Background:

  Mapk8 responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. Phosphorylates heat shock factor protein 4 (HSF4) (By similarity) .

• NCBI Gene ID:

  26419

• Swiss Prot:

  Q91Y86

• Accession Number:

  Q91Y86

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This Mouse Mapk8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-268 amino acids from the Central region of mouse Mapk8.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Immunology, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Rat, Xenopus

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  44 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  Mapk8

• NCBI Official Name:

  Mitogen-activated protein kinase 8

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Sherrin, T., et al. J. Neurosci. 30 (40) :13348-13361 (2010)

• Background Reference 02:

  Morel, C., et al. Mol. Cell. Biol. 30 (19) :4616-4625 (2010)

• Background Reference 03:

  Gao, D., et al. J. Biol. Chem. 285 (39) :29965-29973 (2010)

• Background Reference 04:

  Han, J.S., et al. Anticancer Res. 30 (9) :3407-3412 (2010)

• Other Product Names:

  Mitogen-activated protein kinase 8, MAP kinase 8, MAPK 8, Stress-activated protein kinase JNK1, c-Jun N-terminal kinase 1, Mapk8, Jnk1, Prkm8

• Tested Applications:

  WB

• Physical Properties:

  Liquid