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NRF1 Antibody

CAT: 0223-57-796Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-796Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for 'nuclear factor (erythroid-derived 2) -like 1' which has an official symbol of NFE2L1.
NCBI Gene ID
4899
Swiss Prot
Q16656
Accession Number
Q16656
Host
Rabbit
Reactivity
Human
Immunogen
This NRF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 226-255 amino acids from the Central region of human NRF1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Zebrafish, Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
54 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
NRF1
NCBI Official Name
Nuclear respiratory factor 1
NCBI Organism
Homo sapiens
Background Reference 01
Gonen, N., et al. J. Biol. Chem. 285 (44) :33602-33613 (2010)
Background Reference 02
Zhang, Y., et al. Biochem. J. 430 (3) :497-510 (2010)
Background Reference 03
Shao, D., et al. Mitochondrion 10 (5) :516-527 (2010)
Background Reference 04
Adam, T., et al. Biochem. Biophys. Res. Commun. 398 (3) :495-499 (2010)
Other Product Names
Nuclear respiratory factor 1, NRF-1, Alpha palindromic-binding protein, Alpha-pal, NRF1
Tested Applications
WB
Protein ID
12643732
Physical Properties
Liquid

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