ARFGAP3 Antibody

CAT: 0223-57-785Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-57-785Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1) -bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene.
NCBI Gene ID
26286
Swiss Prot
Q9NP61
Accession Number
Q9NP61
Host
Rabbit
Reactivity
Human
Immunogen
This ARFGAP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 445-473 amino acids from the C-terminal region of human ARFGAP3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
57 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
ARFGAP3
NCBI Official Name
ADP-ribosylation factor GTPase-activating protein 3
NCBI Organism
Homo sapiens
Background Reference 01
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 02
Saitoh, A., et al. J. Biol. Chem. 284 (20) :13948-13957 (2009)
Background Reference 03
Weimer, C., et al. J. Cell Biol. 183 (4) :725-735 (2008)
Background Reference 04
Frigerio, G., et al. Traffic 8 (11) :1644-1655 (2007)
Other Product Names
ADP-ribosylation factor GTPase-activating protein 3, ARF GAP 3, ARFGAP3, ARFGAP1
Tested Applications
WB
Protein ID
21263420
Physical Properties
Liquid

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