PYGM Antibody

• Background:

  PYGM catalyzes and regulates the breakdown of glycogen to glucose-1-phosphate. Defects in PYGM are the cause of glycogen storage disease type 5 (GSD5), also known as McArdle disease. GSD5 is a metabolic disorder resulting in myopathy characterized by exercise intolerance, cramps, muscle weakness and recurrent myoglobinuria.

• NCBI Gene ID:

  5837

• Swiss Prot:

  P11217

• Accession Number:

  P11217

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PYGM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 698-727 amino acids from the C-terminal region of human PYGM.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Monkey

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  97 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PYGM

• NCBI Official Name:

  Glycogen phosphorylase, muscle form

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Tsoi, S.C., et al., J. Soc. Gynecol. Investig. 10 (8) :496-502 (2003) .

• Background Reference 02:

  Bruno, C., et al., Neuromuscul. Disord. 12 (5) :498-500 (2002) .

• Background Reference 03:

  Hadjigeorgiou, G.M., et al., Neuromuscul. Disord. 12 (9) :824-827 (2002) .

• Background Reference 04:

  Deschauer, M., et al., Mol. Genet. Metab. 74 (4) :489-491 (2001) .

• Other Product Names:

  Glycogen phosphorylase, muscle form, Myophosphorylase, PYGM

• Tested Applications:

  WB, IHC-P

• Protein ID:

  3041717

• Physical Properties:

  Liquid