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RFXAP Antibody

CAT: 0223-57-775Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-775Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated ankyrin-containing protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group D. Transcript variants utilizing different polyA signals have been found for this gene.
NCBI Gene ID
5994
Swiss Prot
O00287
Accession Number
O00287
Host
Rabbit
Reactivity
Human
Immunogen
This RFXAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-225 amino acids from the C-terminal region of human RFXAP.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
28 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
RFXAP
NCBI Official Name
Regulatory factor X-associated protein
NCBI Organism
Homo sapiens
Background Reference 01
Laird, K.M., et al. J. Mol. Biol. 403 (1) :40-51 (2010)
Background Reference 02
Bushway, M., et al. Immunogenetics 62 (2) :109-116 (2010)
Background Reference 03
Briggs, L., et al. Proteins 76 (3) :655-664 (2009)
Background Reference 04
Garvie, C.W., et al. Biochim. Biophys. Acta 1779 (12) :797-804 (2008)
Other Product Names
Regulatory factor X-associated protein, RFX-associated protein, RFX DNA-binding complex 36 kDa subunit, RFXAP
Tested Applications
WB
Physical Properties
Liquid

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