ASAP1 Antibody

• Background:

  Possesses phosphatidylinositol 4,5-biphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity) .

• NCBI Gene ID:

  50807

• Swiss Prot:

  Q9ULH1

• Accession Number:

  Q9ULH1

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  This ASAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 360-388 amino acids from the Central region of human ASAP1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  125 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  ASAP1

• NCBI Official Name:

  Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Muller, T., et al. Oncogene 29 (16) :2393-2403 (2010)

• Background Reference 02:

  Nat. Genet. 41 (7) :824-828 (2009)

• Background Reference 03:

  Jian, X., et al. J. Biol. Chem. 284 (3) :1652-1663 (2009)

• Background Reference 04:

  Inoue, H., et al. Mol. Biol. Cell 19 (10) :4224-4237 (2008)

• Other Product Names:

  Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1, 130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein, ADP-ribosylation factor-directed GTPase-activating protein 1, ARF GTPase-activating protein 1, Development and differentiation-enhancing factor 1, DEF-1, Differentiation-enhancing factor 1, PIP2-dependent ARF1 GAP, ASAP1, DDEF1, KIAA1249

• Tested Applications:

  WB

• Protein ID:

  296439459

• Physical Properties:

  Liquid