ASAP1 Antibody

• Background :

  Possesses phosphatidylinositol 4,5-biphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity) .

• NCBI Gene ID :

  50807

• Swiss Prot :

  Q9ULH1

• Accession Number :

  Q9ULH1

• Host :

  Rabbit

• Reactivity :

  Mouse

• Immunogen :

  This ASAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 360-388 amino acids from the Central region of human ASAP1.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Bovine, Rat

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  125 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  ASAP1

• NCBI Official Name :

  Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Muller, T., et al. Oncogene 29 (16) :2393-2403 (2010)

• Background Reference 02 :

  Nat. Genet. 41 (7) :824-828 (2009)

• Background Reference 03 :

  Jian, X., et al. J. Biol. Chem. 284 (3) :1652-1663 (2009)

• Background Reference 04 :

  Inoue, H., et al. Mol. Biol. Cell 19 (10) :4224-4237 (2008)

• Other Product Names :

  Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1, 130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein, ADP-ribosylation factor-directed GTPase-activating protein 1, ARF GTPase-activating protein 1, Development and differentiation-enhancing factor 1, DEF-1, Differentiation-enhancing factor 1, PIP2-dependent ARF1 GAP, ASAP1, DDEF1, KIAA1249

• Tested Applications :

  WB

• Protein ID :

  296439459

• Physical Properties :

  Liquid