NHEJ1 Antibody

• Background:

  Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders.

• NCBI Gene ID:

  79840

• Swiss Prot:

  Q9H9Q4

• Accession Number:

  Q9H9Q4

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This NHEJ1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 268-296 amino acids from the C-terminal region of human NHEJ1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  33 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  NHEJ1

• NCBI Official Name:

  Non-homologous end-joining factor 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Malivert, L., et al. J. Biol. Chem. 285 (34) :26475-26483 (2010)

• Background Reference 02:

  Briggs, F.B., et al. Am. J. Epidemiol. 172 (2) :217-224 (2010)

• Background Reference 03:

  Okada, Y., et al. Hum. Mol. Genet. 19 (11) :2303-2312 (2010)

• Background Reference 04:

  Andres, S.N., et al. Mol. Cell 28 (6) :1093-1101 (2007)

• Other Product Names:

  Non-homologous end-joining factor 1, Protein cernunnos, XRCC4-like factor, NHEJ1, XLF

• Tested Applications:

  WB

• Protein ID:

  74734059

• Physical Properties:

  Liquid