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Mouse Irak1 Antibody

CAT: 0223-57-735Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-735Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Irak1 binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. The kinase activity of this enzyme may not be required for IL-1 signaling. Once phosphorylated, IRAK1 recruits the adapter protein PELI1.
NCBI Gene ID
16179
Swiss Prot
Q62406
Accession Number
Q62406
Host
Rabbit
Reactivity
Mouse
Immunogen
This Mouse Irak1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 405-433 amino acids from the Central region of mouse Irak1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction, Inflammasomes
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
77 kDa
Fragment
Rabbit Ig
Symbol
Irak1
NCBI Official Name
Interleukin-1 receptor-associated kinase 1
NCBI Organism
Mus musculus
Background Reference 01
Vaughan, T., et al. Mol. Immunol. 47 (15) :2515-2518 (2010)
Background Reference 02
Hoshino, K., et al. J. Immunol. 184 (7) :3341-3345 (2010)
Background Reference 03
Dong, J.W., et al. Am. J. Physiol. Heart Circ. Physiol. 298 (3), H1079-H1087 (2010) :
Background Reference 04
Gan, L., et al. Mol. Immunol. 47 (6) :1278-1282 (2010)
Other Product Names
Interleukin-1 receptor-associated kinase 1, IRAK, IRAK-1, Pelle-like protein kinase, mPLK, Irak1, Il1rak
Tested Applications
WB, Flow
Physical Properties
Liquid

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