Products for Research Use Only

HM13 Antibody

CAT: 0223-57-702Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-702Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene.
NCBI Gene ID
81502
Swiss Prot
Q8TCT9
Accession Number
Q8TCT9
Host
Rabbit
Reactivity
Human
Immunogen
This HM13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 325-354 amino acids from the C-terminal region of human HM13.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
41 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
HM13
NCBI Official Name
Minor histocompatibility antigen H13
NCBI Organism
Homo sapiens
Background Reference 01
Sato, T., et al. Biochemistry 45 (28) :8649-8656 (2006)
Background Reference 02
Loureiro, J., et al. Nature 441 (7095) :894-897 (2006)
Background Reference 03
Urny, J., et al. Biochim. Biophys. Acta 1759 (3-4), 159-165 (2006) :
Background Reference 04
Friedmann, E., et al. J. Biol. Chem. 279 (49) :50790-50798 (2004)
Other Product Names
Minor histocompatibility antigen H13, 3423-, Intramembrane protease 1, IMP-1, IMPAS-1, hIMP1, Presenilin-like protein 3, Signal peptide peptidase, HM13, H13, IMP1, PSL3, SPP
Tested Applications
WB
Protein ID
25008563
Physical Properties
Liquid