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QPRT Antibody

CAT: 0223-57-694Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-694Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease.
NCBI Gene ID
23475
Swiss Prot
Q15274
Accession Number
Q15274
Host
Rabbit
Reactivity
Human
Immunogen
This QPRT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 206-234 amino acids from the C-terminal region of human QPRT.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
31 kDa
Fragment
Rabbit Ig
Symbol
QPRT
NCBI Official Name
Nicotinate-nucleotide pyrophosphorylase [carboxylating]
NCBI Organism
Homo sapiens
Background Reference 01
Hinsch, N., et al. BMC Cancer 9, 93 (2009) :
Background Reference 02
Liu, H., et al. J. Mol. Biol. 373 (3) :755-763 (2007)
Background Reference 03
Magni, G., et al. Cell. Mol. Life Sci. 61 (1) :19-34 (2004)
Background Reference 04
Fukuoka, S., et al. Adv. Exp. Med. Biol. 467, 611-614 (1999) :
Other Product Names
Nicotinate-nucleotide pyrophosphorylase [carboxylating], Quinolinate phosphoribosyltransferase [decarboxylating], QAPRTase, QPRTase, QPRT
Tested Applications
WB, IHC-P
Protein ID
296439291
Physical Properties
Liquid

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