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TRIP10 Antibody

CAT: 0223-57-672Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-672Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity) . Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.
NCBI Gene ID
9322
Swiss Prot
Q15642
Accession Number
Q15642
Host
Rabbit
Reactivity
Human
Immunogen
This TRIP10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-144 amino acids from the N-terminal region of human TRIP10.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
68 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
TRIP10
NCBI Official Name
Cdc42-interacting protein 4
NCBI Organism
Homo sapiens
Background Reference 01
Roignot, J., et al. Cancer Lett. 288 (1) :116-123 (2010)
Background Reference 02
Hu, J., et al. Cell. Signal. 21 (11) :1686-1697 (2009)
Background Reference 03
Banerjee, P.P., et al. J. Exp. Med. 204 (10) :2305-2320 (2007)
Background Reference 04
Sugiyama, N., et al. Mol. Cell Proteomics 6 (6) :1103-1109 (2007)
Other Product Names
Cdc42-interacting protein 4, Protein Felic, Salt tolerant protein, hSTP, Thyroid receptor-interacting protein 10, TR-interacting protein 10, TRIP-10, TRIP10, CIP4, STOT, STP
Tested Applications
WB
Protein ID
118572632
Physical Properties
Liquid

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