SMARCB1 Antibody

• Background:

  The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

• NCBI Gene ID:

  6598

• Swiss Prot:

  Q12824

• Accession Number:

  Q12824

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This SMARCB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-81 amino acids from the N-terminal region of human SMARCB1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  44 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  SMARCB1

• NCBI Official Name:

  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bakshi, R., et al. J. Cell. Physiol. 225 (2) :569-576 (2010)

• Background Reference 02:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 03:

  Hadfield, K.D., et al. J. Med. Genet. 47 (8) :567-568 (2010)

• Background Reference 04:

  Kohashi, K., et al. Mod. Pathol. 23 (7) :981-990 (2010)

• Other Product Names:

  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1, BRG1-associated factor 47, BAF47, Integrase interactor 1 protein, SNF5 homolog, hSNF5, SMARCB1, BAF47, INI1, SNF5L1

• Tested Applications:

  WB

• Protein ID:

  51338799

• Physical Properties:

  Liquid