BIN1 Antibody

• Background:

  This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

• NCBI Gene ID:

  274

• Swiss Prot:

  O00499

• Accession Number:

  O00499

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This BIN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 360-389 amino acids from the Central region of human BIN1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  65 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  BIN1

• NCBI Official Name:

  Myc box-dependent-interacting protein 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Biffi, A., et al. Arch. Neurol. 67 (6) :677-685 (2010) Seshadri, S., et al. JAMA 303 (18) :1832-1840 (2010) Yoshida, T., et al. Int. J. Mol. Med. 25 (4) :649-656 (2010) Claeys, K.G., et al. Neurology 74 (6) :519-521 (2010) Hong, T.T., et al. PLoS Biol. (2), E1000312 (2010) :

• Other Product Names:

  Myc box-dependent-interacting protein 1, Amphiphysin II, Amphiphysin-like protein, Box-dependent myc-interacting protein 1, Bridging integrator 1, BIN1, AMPHL

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid