BIN1 Antibody

CAT: 0223-57-663Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-57-663Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
NCBI Gene ID
274
Swiss Prot
O00499
Accession Number
O00499
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This BIN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 360-389 amino acids from the Central region of human BIN1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
65 kDa
Fragment
Rabbit Ig
Symbol
BIN1
NCBI Official Name
Myc box-dependent-interacting protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Biffi, A., et al. Arch. Neurol. 67 (6) :677-685 (2010) Seshadri, S., et al. JAMA 303 (18) :1832-1840 (2010) Yoshida, T., et al. Int. J. Mol. Med. 25 (4) :649-656 (2010) Claeys, K.G., et al. Neurology 74 (6) :519-521 (2010) Hong, T.T., et al. PLoS Biol. (2), E1000312 (2010) :
Other Product Names
Myc box-dependent-interacting protein 1, Amphiphysin II, Amphiphysin-like protein, Box-dependent myc-interacting protein 1, Bridging integrator 1, BIN1, AMPHL
Tested Applications
WB, IHC-P
Physical Properties
Liquid

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