STC2 Antibody

• Background :

  This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers.

• NCBI Gene ID :

  8614

• Swiss Prot :

  O76061

• Accession Number :

  O76061

• Host :

  Rabbit

• Reactivity :

  Mouse

• Immunogen :

  This STC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-302 amino acids from the C-terminal region of human STC2.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Rat

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  33 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  STC2

• NCBI Official Name :

  Stanniocalcin-2

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :

• Background Reference 02 :

  Law, A.Y., et al. Exp. Cell Res. 316 (3) :466-476 (2010)

• Background Reference 03 :

  Volland, S., et al. Int. J. Cancer 125 (9) :2049-2057 (2009)

• Background Reference 04 :

  Ieta, K., et al. Int. J. Cancer 125 (4) :926-931 (2009)

• Other Product Names :

  Stanniocalcin-2, STC-2, Stanniocalcin-related protein, STC-related protein, STCRP, STC2

• Tested Applications :

  WB, IHC-P

• Physical Properties :

  Liquid