PITX2 Antibody

• Background:

  Pilx2 is a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. It plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this protein are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development.

• NCBI Gene ID:

  5308

• Swiss Prot:

  Q99697

• Accession Number:

  Q99697

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PITX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-151 amino acids of human PITX2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat, Zebrafish, Chicken, Xenopus

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  35 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PITX2

• NCBI Official Name:

  Pituitary homeobox 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Engenheiro, E., Clin. Genet. 72 (5), 464-470 (2007)

• Background Reference 02:

  Gudbjartsson, D.F., Nature 448 (7151), 353-357 (2007)

• Background Reference 03:

  Lowry, R.B., Am. J. Med. Genet.143 (11), 1227-1230 (2007)

• Other Product Names:

  Pituitary homeobox 2, ALL1-responsive protein ARP1, Homeobox protein PITX2, Paired-like homeodomain transcription factor 2, RIEG bicoid-related homeobox transcription factor, Solurshin, PITX2, ARP1, RGS, RIEG, RIEG1

• Tested Applications:

  WB, IF

• Protein ID:

  6174907

• Physical Properties:

  Liquid