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PITX2 Antibody

CAT: 0223-57-632Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-632Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Pilx2 is a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. It plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this protein are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development.
NCBI Gene ID
5308
Swiss Prot
Q99697
Accession Number
Q99697
Host
Rabbit
Reactivity
Human
Immunogen
This PITX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-151 amino acids of human PITX2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat, Zebrafish, Chicken, Xenopus
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
35 kDa
Fragment
Rabbit Ig
Symbol
PITX2
NCBI Official Name
Pituitary homeobox 2
NCBI Organism
Homo sapiens
Background Reference 01
Engenheiro, E., Clin. Genet. 72 (5), 464-470 (2007)
Background Reference 02
Gudbjartsson, D.F., Nature 448 (7151), 353-357 (2007)
Background Reference 03
Lowry, R.B., Am. J. Med. Genet.143 (11), 1227-1230 (2007)
Other Product Names
Pituitary homeobox 2, ALL1-responsive protein ARP1, Homeobox protein PITX2, Paired-like homeodomain transcription factor 2, RIEG bicoid-related homeobox transcription factor, Solurshin, PITX2, ARP1, RGS, RIEG, RIEG1
Tested Applications
WB, IF
Protein ID
6174907
Physical Properties
Liquid

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