UMOD Antibody

• Background:

  This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN) . These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.

• NCBI Gene ID:

  7369

• Swiss Prot:

  P07911

• Accession Number:

  P07911

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This UMOD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 352-380 amino acids from the Central region of human UMOD.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  70 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  UMOD

• NCBI Official Name:

  Uromodulin

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Mollsten, A., et al. Scand. J. Urol. Nephrol. 44 (6) :438-444 (2010)

• Background Reference 02:

  Kottgen, A., et al. Nat. Genet. 42 (5) :376-384 (2010)

• Background Reference 03:

  Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)

• Background Reference 04:

  Gudbjartsson, D.F., et al. PLoS Genet. (7), E1001039 (2010) :

• Other Product Names:

  Uromodulin, Tamm-Horsfall urinary glycoprotein, THP, Uromodulin, secreted form, UMOD

• Tested Applications:

  WB, IHC-P

• Protein ID:

  137116

• Physical Properties:

  Liquid