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RNF19A Antibody

CAT: 0223-57-576Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-576Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded this gene contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquintin ligase that is localized in Lewy bodies (LBs), a characteristic neuronal inclusion in Parkinson's disease (PD) brains. This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein is found to bind and ubiquitylate synphilin 1 (SNCAIP), which is a interacting protein of alpha synuclein in neurons, and a major component of LB. Alternatively spliced transcript variants encoding the same protein have been reported.
NCBI Gene ID
25897
Swiss Prot
Q9NV58
Accession Number
Q9NV58
Host
Rabbit
Reactivity
Human
Immunogen
This RNF19A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 384-413 amino acids from the Central region of human RNF19A.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Pig
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
91 kDa
Fragment
Rabbit Ig
Symbol
RNF19A
NCBI Official Name
E3 ubiquitin-protein ligase RNF19A
NCBI Organism
Homo sapiens
Background Reference 01
Huh, J.W., et al. Gene 424 (1-2), 63-70 (2008) :
Background Reference 02
Matsuoka, S., et al. Science 316 (5828) :1160-1166 (2007)
Background Reference 03
Ishigaki, S., et al. Neurobiol. Dis. 25 (2) :331-341 (2007)
Background Reference 04
Huang, Y., et al. J. Biol. Chem. 281 (17) :11610-11617 (2006)
Other Product Names
E3 ubiquitin-protein ligase RNF19A, 632-, Double ring-finger protein, Dorfin, RING finger protein 19A, p38, RNF19A, RNF19
Tested Applications
WB, IHC-P
Protein ID
116242764
Physical Properties
Liquid

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