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APLNR Antibody

CAT: 0223-57-494Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-494Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified.
NCBI Gene ID
187
Swiss Prot
P35414
Accession Number
P35414
Host
Rabbit
Reactivity
Human
Immunogen
This APLNR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-244 amino acids from the Central region of human APLNR.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Neuroscience, Signal Transduction, Growth Factors
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
43 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
APLNR
NCBI Official Name
Apelin receptor
NCBI Organism
Homo sapiens
Background Reference 01
Tao, Y., et al. Invest. Ophthalmol. Vis. Sci. 51 (8) :4237-4242 (2010)
Background Reference 02
Zhao, Q., et al. Am. J. Hypertens. 23 (6) :606-613 (2010)
Background Reference 03
Lee, D.K., et al. Biochem. Biophys. Res. Commun. 395 (2) :185-189 (2010)
Background Reference 04
Falcao-Pires, I., et al. Expert Opin. Ther. Targets 14 (3) :231-241 (2010)
Other Product Names
Apelin receptor, Angiotensin receptor-like 1, G-protein coupled receptor APJ, G-protein coupled receptor HG11, APLNR, AGTRL1, APJ
Tested Applications
WB
Protein ID
543823
Physical Properties
Liquid

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