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NCK2 Antibody

CAT: 0223-57-480Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-480Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
NCBI Gene ID
8440
Swiss Prot
O43639
Accession Number
O43639
Host
Rabbit
Reactivity
Human
Immunogen
This NCK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-92 amino acids from the N-terminal region of human NCK2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
43 kDa
Fragment
Rabbit Ig
Symbol
NCK2
NCBI Official Name
Cytoplasmic protein NCK2
NCBI Organism
Homo sapiens
Background Reference 01
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 02
Guan, S., et al. J. Invest. Dermatol. 129 (8) :1909-1920 (2009)
Background Reference 03
Liu, J., et al. PLoS ONE (11), E7805 (2009) :
Background Reference 04
Akiyama, M., et al. BrOphthalmol 92 (9) :1293-1296 (2008)
Other Product Names
Cytoplasmic protein NCK2, Growth factor receptor-bound protein 4, NCK adaptor protein 2, Nck-2, SH2/SH3 adaptor protein NCK-beta, NCK2, GRB4
Tested Applications
WB, IHC-P
Physical Properties
Liquid

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