GRIA3 Antibody

• Background:

  Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate) -sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G) . Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties.

• NCBI Gene ID:

  2892

• Swiss Prot:

  P42263

• Accession Number:

  P42263

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This GRIA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 188-217 amino acids from the N-terminal region of human GRIA3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Monkey, Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  101 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  GRIA3

• NCBI Official Name:

  Glutamate receptor 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ripka, S., et al. Neoplasia 12 (8) :659-667 (2010)

• Background Reference 02:

  Liu, Q., et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 26 (4) :376-378 (2010)

• Background Reference 03:

  Feyissa, A.M., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry 34 (2) :279-283 (2010)

• Background Reference 04:

  Marek, G.J., et al. Mol. Pharmacol. 77 (3) :317-326 (2010)

• Other Product Names:

  Glutamate receptor 3, GluR-3, AMPA-selective glutamate receptor 3, GluR-C, GluR-K3, Glutamate receptor ionotropic, AMPA 3, GluA3, GRIA3, GLUR3, GLURC

• Tested Applications:

  WB

• Protein ID:

  77416864

• Physical Properties:

  Liquid