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GRIA4 Antibody

CAT: 0223-55-371Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-371Size:400 µL
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Background
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate) -sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G) . Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq].
NCBI Gene ID
2893
Swiss Prot
P48058
Accession Number
P48058
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This GRIA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 259-287 amino acids from the Central region of human GRIA4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Monkey, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
101 kDa
Fragment
Rabbit Ig
Symbol
GRIA4
NCBI Official Name
Glutamate receptor 4
NCBI Organism
Homo sapiens
Background Reference 01
Need, A.C., et al. Eur. J. Hum. Genet. 17 (7) :946-957 (2009)
Background Reference 02
Volpi, S., et al.Clin Psychiatry 70 (6) :801-809 (2009)
Background Reference 03
Kessels, H.W., et al. Neuron 61 (3) :340-350 (2009)
Background Reference 04
Arai, S., et al. Psychiatr. Genet. 19 (1) :6-13 (2009)
Other Product Names
Glutamate receptor 4, GluR-4, GluR4, AMPA-selective glutamate receptor 4, GluR-D, Glutamate receptor ionotropic, AMPA 4, GluA4, GRIA4, GLUR4
Tested Applications
WB, IHC-P
Protein ID
218512059
Physical Properties
Liquid

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