MIST Antibody

• Background:

  MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515) . MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420) -mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140) -mediated mast cell degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al., 2000, 2001 [PubMed 10744659] [PubMed 11463797]) .

• NCBI Gene ID:

  116449

• Swiss Prot:

  Q7Z7G1

• Accession Number:

  Q7Z7G1

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MIST antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 281-308 amino acids from the Central region of human MIST.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  50 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CLNK

• NCBI Official Name:

  Cytokine-dependent hematopoietic cell linker

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Background Reference 02:

  Cronin, S., et al. Eur. J. Hum. Genet. 17 (2) :213-218 (2009)

• Background Reference 03:

  Goitsuka, R., et al. J. Biol. Chem. 276 (38) :36043-36050 (2001)

• Background Reference 04:

  Goitsuka, R., et al. Int. Immunol. 12 (4) :573-580 (2000)

• Other Product Names:

  Cytokine-dependent hematopoietic cell linker, Mast cell immunoreceptor signal transducer, CLNK, MIST

• Tested Applications:

  WB

• Protein ID:

  166217263

• Physical Properties:

  Liquid