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ACK1 Antibody

CAT: 0223-57-363Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-363Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP) -stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.
NCBI Gene ID
10188
Swiss Prot
Q07912
Accession Number
Q07912
Host
Rabbit
Reactivity
Human
Immunogen
This ACK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-290 amino acids from the Central region of human ACK1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
115 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
TNK2
NCBI Official Name
Activated CDC42 kinase 1
NCBI Organism
Homo sapiens
Background Reference 01
Mahajan, K., et al. J. Cell. Physiol. 224 (2) :327-333 (2010)
Background Reference 02
Chua, B.T., et al. Mol Oncol 4 (4) :323-334 (2010)
Background Reference 03
Prieto-Echague, V., et al. J. Biol. Chem. 285 (14) :10605-10615 (2010)
Background Reference 04
Lin, Q., et al. Mol. Cell. Biol. 30 (6) :1541-1554 (2010)
Other Product Names
Activated CDC42 kinase 1, ACK-1, Tyrosine kinase non-receptor protein 2, TNK2, ACK1
Tested Applications
WB
Protein ID
229462980
Physical Properties
Liquid

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