Mouse Nlk Antibody

• Background:

  Role in cell fate determination, required for differentiation of bone marrow stromal cells. Acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta-catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. May suppress a wide range of transcription factors by phosphorylation of the coactivator, CREBBP. Involved in TGFbeta-mediated mesoderm induction, acting downstream of MAP3K7/TAK1 to phosphorylate STAT3.

• NCBI Gene ID:

  18099

• Swiss Prot:

  O54949

• Accession Number:

  O54949

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This Mouse Nlk antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 408-436 amino acids from the C-terminal region of mouse Nlk.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  58 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  Nlk

• NCBI Official Name:

  Serine/threonine-protein kinase NLK

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Li, M., et al. J. Biol. Chem. 285 (18) :13397-13404 (2010)

• Background Reference 02:

  Nifuji, A., et al. Exp. Cell Res. 316 (7) :1127-1136 (2010)

• Background Reference 03:

  Ishitani, T., et al. Nat. Cell Biol. 12 (3) :278-285 (2010)

• Background Reference 04:

  Martinez, G., et al. Invest. Ophthalmol. Vis. Sci. 50 (10) :4794-4806 (2009)

• Other Product Names:

  Serine/threonine-protein kinase NLK, Nemo-like kinase, Nlk {ECO:0000312|EMBL:AAC244991}

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid