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Mouse Nlk Antibody

CAT: 0223-57-359Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-359Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Role in cell fate determination, required for differentiation of bone marrow stromal cells. Acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta-catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. May suppress a wide range of transcription factors by phosphorylation of the coactivator, CREBBP. Involved in TGFbeta-mediated mesoderm induction, acting downstream of MAP3K7/TAK1 to phosphorylate STAT3.
NCBI Gene ID
18099
Swiss Prot
O54949
Accession Number
O54949
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This Mouse Nlk antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 408-436 amino acids from the C-terminal region of mouse Nlk.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
58 kDa
Fragment
Rabbit Ig
Symbol
Nlk
NCBI Official Name
Serine/threonine-protein kinase NLK
NCBI Organism
Mus musculus
Background Reference 01
Li, M., et al. J. Biol. Chem. 285 (18) :13397-13404 (2010)
Background Reference 02
Nifuji, A., et al. Exp. Cell Res. 316 (7) :1127-1136 (2010)
Background Reference 03
Ishitani, T., et al. Nat. Cell Biol. 12 (3) :278-285 (2010)
Background Reference 04
Martinez, G., et al. Invest. Ophthalmol. Vis. Sci. 50 (10) :4794-4806 (2009)
Other Product Names
Serine/threonine-protein kinase NLK, Nemo-like kinase, Nlk {ECO:0000312|EMBL:AAC244991}
Tested Applications
WB, IHC-P
Physical Properties
Liquid

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