POF1B Antibody

• Background:

  Premature ovarian failure (POF) is characterized by primary or secondary amenorrhea in women less than 40 years old. Two POF susceptibility regions called 'POF1' and 'POF2' have been identified by breakpoint mapping of X-autosome translocations. POF1 extends from Xq21-qter while POF2 extends from Xq13.3 to Xq21.1. This gene, POF1B, resides in the POF2 region. This gene is expressed at trace levels in mouse prenatal ovary and is barely detectable or absent from adult ovary, in human and in the mouse respectively. This gene's expression is restricted to epithelia with its highest expression in the epidermis, and oro-pharyngeal and gastro-intestinal tracts. The protein encoded by this gene binds non-muscle actin filaments. The role this gene may play in the etiology of premature ovarian failure remains to be determined.

• NCBI Gene ID:

  79983

• Swiss Prot:

  Q8WVV4

• Accession Number:

  Q8WVV4

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  This POF1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 337-366 amino acids from the Central region of human POF1B.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  68 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  POF1B

• NCBI Official Name:

  Protein POF1B

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Rizzolio, F., et al. Gene Expr. Patterns 7 (4) :529-534 (2007)

• Background Reference 02:

  Lacombe, A., et al. Am. J. Hum. Genet. 79 (1) :113-119 (2006)

• Background Reference 03:

  Bione, S., et al. Hum. Reprod. 19 (12) :2759-2766 (2004)

• Background Reference 04:

  Bione, S., et al. Semin. Reprod. Med. 18 (1) :51-57 (2000)

• Other Product Names:

  Protein POF1B, Premature ovarian failure protein 1B, POF1B

• Tested Applications:

  WB

• Protein ID:

  332278224

• Physical Properties:

  Liquid