RANGAP1 Antibody

• Background :

  RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.

• NCBI Gene ID :

  5905

• Swiss Prot :

  P46060

• Accession Number :

  P46060

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This RANGAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-49 amino acids from the N-terminal region of human RANGAP1.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cell Cycle

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  64 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  RANGAP1

• NCBI Official Name :

  Ran GTPase-activating protein 1

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Zhang, J., et al. Biochem. Biophys. Res. Commun. 375 (2) :252-255 (2008)

• Background Reference 02 :

  Zuccolo, M., et al. EMBO J. 26 (7) :1853-1864 (2007)

• Background Reference 03 :

  Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :

• Background Reference 04 :

  Vertegaal, A.C., et al. Mol. Cell Proteomics 5 (12) :2298-2310 (2006)

• Other Product Names :

  Ran GTPase-activating protein 1, RanGAP1, RANGAP1, KIAA1835, SD

• Tested Applications :

  WB, IHC-P

• Protein ID :

  1172922

• Physical Properties :

  Liquid