RANGAP1 Antibody

• Background:

  RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.

• NCBI Gene ID:

  5905

• Swiss Prot:

  P46060

• Accession Number:

  P46060

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This RANGAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-49 amino acids from the N-terminal region of human RANGAP1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  64 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  RANGAP1

• NCBI Official Name:

  Ran GTPase-activating protein 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Zhang, J., et al. Biochem. Biophys. Res. Commun. 375 (2) :252-255 (2008)

• Background Reference 02:

  Zuccolo, M., et al. EMBO J. 26 (7) :1853-1864 (2007)

• Background Reference 03:

  Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :

• Background Reference 04:

  Vertegaal, A.C., et al. Mol. Cell Proteomics 5 (12) :2298-2310 (2006)

• Other Product Names:

  Ran GTPase-activating protein 1, RanGAP1, RANGAP1, KIAA1835, SD

• Tested Applications:

  WB, IHC-P

• Protein ID:

  1172922

• Physical Properties:

  Liquid