ARHGDIB Antibody

• Background:

  Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs) . The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]) .

• NCBI Gene ID:

  397

• Swiss Prot:

  P52566

• Accession Number:

  P52566

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ARHGDIB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-188 amino acids from the C-terminal region of human ARHGDIB.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  23 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  ARHGDIB

• NCBI Official Name:

  Rho GDP-dissociation inhibitor 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Niu, H., et al. Oncol. Rep. 24 (2) :465-471 (2010)

• Background Reference 02:

  Zhen, H., et al. Int. J. Gynecol. Cancer 20 (3) :316-322 (2010)

• Background Reference 03:

  Guey, L.T., et al. Eur. Urol. 57 (2) :283-292 (2010)

• Background Reference 04:

  Said, N., et al. Cancer Metastasis Rev. 28 (3-4), 327-333 (2009) :

• Other Product Names:

  Rho GDP-dissociation inhibitor 2, Rho GDI 2, Ly-GDI, Rho-GDI beta, ARHGDIB, GDIA2, GDID4, RAP1GN1

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid