CTTN Antibody

• Background:

  This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.

• NCBI Gene ID:

  2017

• Swiss Prot:

  Q14247

• Accession Number:

  Q14247

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CTTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-302 amino acids from the Central region of human CTTN.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Chicken

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  62 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CTTN

• NCBI Official Name:

  Src substrate cortactin

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Croucher, D.R., et al. Mol. Cell. Biol. 30 (21) :5057-5070 (2010)

• Background Reference 02:

  Eiseler, T., et al. J. Biol. Chem. 285 (24) :18672-18683 (2010)

• Background Reference 03:

  Xu, X.Z., et al. Mod. Pathol. 23 (2) :187-196 (2010)

• Background Reference 04:

  Saitoh, Y., et al. Int. J. Oncol. 35 (6) :1277-1288 (2009)

• Other Product Names:

  Src substrate cortactin, Amplaxin, Oncogene EMS1, CTTN, EMS1

• Tested Applications:

  WB, IHC-P

• Protein ID:

  215273892

• Physical Properties:

  Liquid