Products for Research Use Only
RegisterLogin

CTTN Antibody

CAT: 0223-57-227Size: 400 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-57-227Size:400 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.
NCBI Gene ID
2017
Swiss Prot
Q14247
Accession Number
Q14247
Host
Rabbit
Reactivity
Human
Immunogen
This CTTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-302 amino acids from the Central region of human CTTN.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Chicken
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
62 kDa
Fragment
Rabbit Ig
Symbol
CTTN
NCBI Official Name
Src substrate cortactin
NCBI Organism
Homo sapiens
Background Reference 01
Croucher, D.R., et al. Mol. Cell. Biol. 30 (21) :5057-5070 (2010)
Background Reference 02
Eiseler, T., et al. J. Biol. Chem. 285 (24) :18672-18683 (2010)
Background Reference 03
Xu, X.Z., et al. Mod. Pathol. 23 (2) :187-196 (2010)
Background Reference 04
Saitoh, Y., et al. Int. J. Oncol. 35 (6) :1277-1288 (2009)
Other Product Names
Src substrate cortactin, Amplaxin, Oncogene EMS1, CTTN, EMS1
Tested Applications
WB, IHC-P
Protein ID
215273892
Physical Properties
Liquid

Related Products

CatalogName
64-160WAS Antibody
60-596WAS Antibody
13-349WAS Antibody
62-828Neprilysin Antibody
61-580CAPZB Antibody
55-580HCG_2024410 Antibody
30-580ACPT Antibody
19-580FABP3 Antibody
15-580POMGNT2 Antibody
5217-01mgPNAS4 Antibody

Alternative Products

CatalogName
70R-16665CTTN antibody

Popular Products