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HBG1 Antibody

CAT: 0223-57-207Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-207Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1) . The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.
NCBI Gene ID
3047
Swiss Prot
P69891
Accession Number
P69891
Host
Rabbit
Reactivity
Human
Immunogen
This HBG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-85 amino acids from the Central region of human HBG1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
16 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
HBG1
NCBI Official Name
Hemoglobin subunit gamma-1
NCBI Organism
Homo sapiens
Background Reference 01
Zhou, D., et al. Nat. Genet. 42 (9) :742-744 (2010)
Background Reference 02
Miccio, A., et al. Mol. Cell. Biol. 30 (14) :3460-3470 (2010)
Background Reference 03
Nuinoon, M., et al. Hum. Genet. (2009) In press :
Background Reference 04
Da Cunha, A.F., et al. Hemoglobin 33 (6) :439-447 (2009)
Other Product Names
Hemoglobin subunit gamma-1, Gamma-1-globin, Hb F Agamma, Hemoglobin gamma-1 chain, Hemoglobin gamma-A chain, HBG1
Tested Applications
WB
Protein ID
56749860
Physical Properties
Liquid

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