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MMP2 Antibody

CAT: 0223-57-205Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-205Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
4313
Swiss Prot
P08253
Accession Number
P08253
Host
Rabbit
Reactivity
Human
Immunogen
This MMP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 303-331 amino acids from the Central region of human MMP2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Obesity
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat, Rabbit, Chicken
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
74 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
MMP2
NCBI Official Name
72 kDa type IV collagenase
NCBI Organism
Homo sapiens
Background Reference 01
Beshir, A.B., et al. Cancer Lett. 299 (2) :137-149 (2010)
Background Reference 02
Alakus, H., et al. WorldSurg 34 (12) :2853-2859 (2010)
Background Reference 03
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
Background Reference 04
Nikopensius, T., et al. Birth Defects Res. PartClin. Mol. Teratol. 88 (9) :748-756 (2010)
Other Product Names
72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A, Matrix metalloproteinase-2, MMP-2, TBE-1, PEX, MMP2, CLG4A
Tested Applications
WB
Protein ID
116856
Physical Properties
Liquid

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