MMP2 Antibody

• Background:

  Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  4313

• Swiss Prot:

  P08253

• Accession Number:

  P08253

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MMP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 303-331 amino acids from the Central region of human MMP2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Obesity

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat, Rabbit, Chicken

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  74 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  MMP2

• NCBI Official Name:

  72 kDa type IV collagenase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Beshir, A.B., et al. Cancer Lett. 299 (2) :137-149 (2010)

• Background Reference 02:

  Alakus, H., et al. WorldSurg 34 (12) :2853-2859 (2010)

• Background Reference 03:

  Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :

• Background Reference 04:

  Nikopensius, T., et al. Birth Defects Res. PartClin. Mol. Teratol. 88 (9) :748-756 (2010)

• Other Product Names:

  72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A, Matrix metalloproteinase-2, MMP-2, TBE-1, PEX, MMP2, CLG4A

• Tested Applications:

  WB

• Protein ID:

  116856

• Physical Properties:

  Liquid