MMP3 Antibody

• Background:

  Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP3 is an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation.

• NCBI Gene ID:

  4314

• Swiss Prot:

  P08254

• Accession Number:

  P08254

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MMP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 298-327 amino acids from the Central region of human MMP3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  54 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  MMP3

• NCBI Official Name:

  Stromelysin-1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Sage, E.H., et al., J. Biol. Chem. 278 (39) :37849-37857 (2003) .

• Background Reference 02:

  Matsuyama, A., et al., Circulation 108 (12) :1469-1473 (2003) .

• Background Reference 03:

  Mercapide, J., et al., Int. J. Cancer 106 (5) :676-682 (2003) .

• Background Reference 04:

  Bodemer, C., et al., J. Invest. Dermatol. 121 (2) :273-279 (2003) .

• Other Product Names:

  Stromelysin-1, SL-1, Matrix metalloproteinase-3, MMP-3, Transin-1, MMP3, STMY1

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  116857

• Physical Properties:

  Liquid