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P4HA3 Antibody

CAT: 0223-57-200Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-200Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.
NCBI Gene ID
283208
Swiss Prot
Q7Z4N8
Accession Number
Q7Z4N8
Host
Rabbit
Reactivity
Human
Immunogen
This P4HA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 274-303 amino acids from the Central region of human P4HA3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
61 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
P4HA3
NCBI Official Name
Prolyl 4-hydroxylase subunit alpha-3
NCBI Organism
Homo sapiens
Background Reference 01
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Background Reference 02
Koivunen, P., et al. J. Biol. Chem. 281 (39) :28712-28720 (2006)
Background Reference 03
Kukkola, L., et al. J. Biol. Chem. 278 (48) :47685-47693 (2003)
Background Reference 04
Van Den Diepstraten, C., et al. Circulation 108 (5) :508-511 (2003)
Other Product Names
Prolyl 4-hydroxylase subunit alpha-3, 4-PH alpha-3, Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-3, P4HA3
Tested Applications
WB
Protein ID
74738714
Physical Properties
Liquid

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