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NFE2 Antibody

CAT: 0223-57-123Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-123Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR) . This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.
NCBI Gene ID
4778
Swiss Prot
Q16621
Accession Number
Q16621
Host
Rabbit
Reactivity
Human
Immunogen
This NFE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 312-340 amino acids from the C-terminal region of human NFE2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
41 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
NFE2
NCBI Official Name
Transcription factor NF-E2 45 kDa subunit
NCBI Organism
Homo sapiens
Background Reference 01
Wang, W., et al. Blood 116 (2) :254-266 (2010)
Background Reference 02
Zhou, Z., et al. J. Biol. Chem. 285 (21) :15894-15905 (2010)
Background Reference 03
Motohashi, H., et al. Blood 115 (3) :677-686 (2010)
Background Reference 04
Lee, T.L., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (1) :52-57 (2010)
Other Product Names
Transcription factor NF-E2 45 kDa subunit, Leucine zipper protein NF-E2, Nuclear factor, erythroid-derived 2 45 kDa subunit, p45 NF-E2, NFE2
Tested Applications
WB
Protein ID
6831585
Physical Properties
Liquid

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