MCOLN1 Antibody

• Background:

  This gene encodes a memberof the transient receptor potential (TRP) cation channel gene family. The transmembrane protein localizes to intracellular vesicular membranes including lysosomes, and functions in the late endocytic pathway and in the regulation of lysosomal exocytosis. The channel is permeable to Ca (2+), Fe (2+), Na (+), K (+), and H (+), and is modulated by changes in Ca (2+) concentration. Mutations in this gene result in mucolipidosis type IV.

• NCBI Gene ID:

  57192

• Swiss Prot:

  Q9GZU1

• Accession Number:

  Q9GZU1

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MCOLN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 531-560 amino acids from the C-terminal region of human MCOLN1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Monkey, Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  65 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  MCOLN1

• NCBI Official Name:

  Mucolipin-1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Eichelsdoerfer, J.L., et al. J. Biol. Chem. 285 (45) :34304-34308 (2010)

• Background Reference 02:

  Curcio-Morelli, C., et al. J. Cell. Physiol. 222 (2) :328-335 (2010)

• Background Reference 03:

  Vergarajauregui, S., et al. J. Biol. Chem. 284 (52) :36357-36366 (2009)

• Background Reference 04:

  Ballif, B.A., et al. Mol. Cell Proteomics 3 (11) :1093-1101 (2004)

• Other Product Names:

  Mucolipin-1, MG-2, Mucolipidin, MCOLN1, ML4

• Tested Applications:

  WB, IHC-P

• Protein ID:

  50401163

• Physical Properties:

  Liquid