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SMC1A Antibody

CAT: 0223-57-109Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-109Size:400 µL
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Background
Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. [provided by RefSeq].
NCBI Gene ID
8243
Swiss Prot
Q14683
Accession Number
Q14683
Host
Rabbit
Reactivity
Human
Immunogen
This SMC1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-336 amino acids from the N-terminal region of human SMC1A.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
143 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
SMC1A
NCBI Official Name
Structural maintenance of chromosomes protein 1A
NCBI Organism
Homo sapiens
Background Reference 01
Limongelli, G., et al. Am. J. Med. Genet.152A (8), 2127-2129 (2010) :
Background Reference 02
Homme, C., et al. Oncol. Rep. 24 (1) :47-56 (2010)
Background Reference 03
Pie, J., et al. Am. J. Med. Genet.152A (4), 924-929 (2010) :
Background Reference 04
Wong, R.W. Cell Cycle 9 (1) :198-200 (2010)
Other Product Names
Structural maintenance of chromosomes protein 1A, SMC protein 1A, SMC-1-alpha, SMC-1A, Sb18, SMC1A, DXS423E, KIAA0178, SB18, SMC1, SMC1L1
Tested Applications
WB
Protein ID
29336622
Physical Properties
Liquid

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