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EIF2S1 Antibody

CAT: 0223-57-063Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-57-063Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161) . The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]) .
NCBI Gene ID
1965
Swiss Prot
P05198
Accession Number
P05198
Host
Rabbit
Reactivity
Mouse
Immunogen
This EIF2S1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 60-89 amino acids from the N-terminal region of human EIF2S1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rat, Chicken, Yeast, Bovine, Drosophila
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
36 kDa
Fragment
Rabbit Ig
Symbol
EIF2S1
NCBI Official Name
Eukaryotic translation initiation factor 2 subunit 1
NCBI Organism
Homo sapiens
Background Reference 01
Shiota, M., et al. Int. J. Oncol. 36 (6) :1521-1531 (2010)
Background Reference 02
Kulkarni, A.P., et al. Indian J. Biochem. Biophys. 47 (2) :67-74 (2010)
Background Reference 03
Wehner, K.A., et al. Mol. Cell. Biol. 30 (8) :2006-2016 (2010)
Background Reference 04
Backes, S., et al. J. Gen. Virol. 91 (PT 2), 470-482 (2010) :
Other Product Names
Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit alpha, eIF-2-alpha, eIF-2A, eIF-2alpha, EIF2S1, EIF2A
Tested Applications
WB, IHC-P, IF
Protein ID
124200
Physical Properties
Liquid

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