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MYOM1 Antibody

CAT: 0223-57-047Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-047Size:400 µL
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Background
The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD (myomesin 1) and 165 kD (myomesin 2) . This protein, myomesin 1, like myomesin 2, titin, and other myofibrillar proteins contains structural modules with strong homology to either fibronectin type III (motif I) or immunoglobulin C2 (motif II) domains. Myomesin 1 and myomesin 2 each have a unique N-terminal region followed by 12 modules of motif I or motif II, in the arrangement II-II-I-I-I-I-I-II-II-II-II-II. The two proteins share 50% sequence identity in this repeat-containing region. The head structure formed by these 2 proteins on one end of the titin string extends into the center of the M band. The integrating structure of the sarcomere arises from muscle-specific members of the superfamily of immunoglobulin-like proteins. Alternatively spliced transcript variants encoding different isoforms have been identified.
NCBI Gene ID
8736
Swiss Prot
P52179
Accession Number
P52179
Host
Rabbit
Reactivity
Human
Immunogen
This MYOM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 904-933 amino acids from the Central region of human MYOM1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
188 kDa
Fragment
Rabbit Ig
Symbol
MYOM1
NCBI Official Name
Myomesin-1
NCBI Organism
Homo sapiens
Background Reference 01
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 02
Schoenauer, R., et al. J. Mol. Biol. 349 (2) :367-379 (2005)
Background Reference 03
Hornemann, T., et al. J. Mol. Biol. 332 (4) :877-887 (2003)
Background Reference 04
Porter, J.D., et al. J. Exp. Biol. 206 (PT 17), 3101-3112 (2003) :
Other Product Names
Myomesin-1, 190 kDa connectin-associated protein, 190 kDa titin-associated protein, Myomesin family member 1, MYOM1
Tested Applications
WB, IHC-P
Protein ID
212276443
Physical Properties
Liquid

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