BEAN Antibody

• Background:

  The protein encoded by this gene is one of several proteins that interact with NEDD4, a member of a family of ubiquitin-protein ligases. These proteins have PY motifs in common that bind to the WW domains of NEDD4. NEDD4 is developmentally regulated, and is highly expressed in embryonic tissues. Mutations in this gene (i.e., intronic insertions of >100 copies of pentanucleotide repeats including a (TGGAA) n sequence) are associated with spinocerebellar ataxia type 31. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  146227

• Swiss Prot:

  Q3B7T3

• Accession Number:

  Q3B7T3

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This BEAN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-73 amino acids from the N-terminal region of human BEAN.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  29 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  BEAN1

• NCBI Official Name:

  Protein BEAN1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Sato, N., et al. Am. J. Hum. Genet. 85 (5) :544-557 (2009)

• Background Reference 02:

  Jolliffe, C.N., et al. Biochem. J. 351 PT 3, 557-565 (2000) :

• Other Product Names:

  Protein BEAN1, Brain-expressed protein associating with Nedd4 homolog, BEAN, BEAN1

• Tested Applications:

  WB, IHC-P

• Protein ID:

  190360694

• Physical Properties:

  Liquid